Lin, Chin-Hsien
林靜嫻醫師
林靜嫻醫師現任臺大醫院神經部教授，並兼任台大醫學院分子醫學研究所、醫學工程研究所與腦與心智研究所教授。臨床面向也擔任臺大醫院臨床神經暨行為醫學中心主任。林教授的研究專長與興趣集中於巴金森氏病(Parkinson’s Disease)、動作障礙疾病(movement disorders)、神經退化性疾病(neurodegenerative disease)、腸-腦軸(gut-brain axis)與神經基因醫學，相關研究皆發表於國內外優良學術期刊並廣受引用。林教授也因其研究成就受邀擔任世界神經學會教育委員會委員、世界動作障礙學會學術委員會委員等國際學術單位職務，並擔任台灣動作障礙學會理事長。
- 著作 ：
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- Sung-Pin Fan, Ya-Fang Chen, Cheng-Hsuan Li, Yih-Chih Kuo, Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu, Tai-Chung Tseng, Tung-Hung Su, Chien-Ting Hsu, Huey-Ling Chen, Chin-Hsien Lin*, Yen-Hsuan Ni*. Topographical metal burden correlates with brain atrophy and clinical severity in Wilson’s disease. Neuroimage 2024, in press.
- Jagota P, Phutrakool P, Kamble N, Dang THT, Aldaajani Z, Hatano T, Hoskere Sreenivasa DK, Tripura T, Kukkle PL, Jeon B, Nishikawa N, Oji Y, Tran TN, Susatia F, Fabbri M, Leung C, Alonso Canovas A, Kamel WA, Pal PK, Rakesh K, Abu Snineh M, Chairangsaris P, Lolekha P, Jamora RDG, Mohamed Ibrahim N, Desa SHM, Tan AH, Toh TS, Obaid M, Fung VSC, Lang A, Lin CH, Regragui W, Bouslam N, Bhidayasiri R. Exercise Habits in People with Parkinson’s: A Multinational Survey. Mov Disord Clin Pract 2024 Aug 29. doi: 10.1002/mdc3.14197.
- Norlinah Mohamed Ibrahim* and Chin-Hsien Lin*. Early Onset Parkinsonism: Differential diagnosis and what not to miss. Parkinsonism & Related Disorders. 2024 Aug 15:107100. doi: 10.1016/j.parkreldis.2024.107100.
- Peng-Hsiang Liao, Hsiao-Yen Tung, Wee Shin Lim, Jyh-Shing Roger Jang, Hsun Li, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu, Chin-Hsien Lin*. Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson’s disease. Neurological Sciences. 2024 in press.
- Sung-Ju Hsueh, Chin-Hsien Lin, Ni-Chung Lee, Tung-Ming Chang, Sung-Pin Fan, Wan-De Huang, Yea-Huey Lin, Li-Kai Tsai, Yin-Hsiu Chien, Ming-Jen Lee, Wuh-Liang Hwu, Hsueh Wen Hsueh*, Chih-Chao Yang*. Unique clinical and electrophysiological features in the peripheral nerve system in patients with sialidosis – a case series study. Orphanet J Rare Dis 2024 May 24;19(1):217.
- Lin YH, Wang LW, Chen YH, Chan YC, Hu SH, Wu SY, Chiang CS, Huang GJ, Yang SD, Chu SW, Wang KC, Lin CH, Huang PH, Cheng HJ, Chen BC, Chu LA. Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain. Elife. 2024 May 22;13:RP93212. doi: 10.7554/eLife.93212.
- Chang JC, Chang HS, Chao YC, Huang CS, Lin CH, Wu ZS, Chang HJ, Liu CS, Chuang CS. Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport. Biology (Basel). 2024;13(4):231.
- Huan-Yun Chen, Chia-Yu Liao, Hsun Li. Yi-Ci Ke Lin, Chin-Hsien Lin,* Teng, Shu-Chun*. ATM-mediated co-chaperone DNAJB11 phosphorylation facilitates α-synuclein folding upon DNA double-stranded breaks. NAR Molecular Medicine. 2024 in press
- Pin-Shiuan Chena, Ying-Fa Chen, Jian-Ying Chiu, Meng-Chen Wu, MD, Chun-Hwei Tai, Yung-Yee Chang, Min-Yu Lan, Han-I Lin, Ni-Chung Lee, Chin-Hsien Lin*. Genetic analysis of IRF2BPL in a Taiwanese dystonia cohort: the genotype and phenotype correlation. Annals of Clinical and Translational Neurology 2024, in press. doi: 10.1002/mds.29802.
- Chih-Hsin Ou-Yang, Pin-Shiuan Chen, Chin-Hsien Lin*. Generation of a human induced pluripotent stem cell line NTUHi004-A from a patient with Leigh syndrome harboring a homozygous missense mutation c.836 T > G (p.Met279Arg) in NDUFAF5 gene. Stem Cell Research 2024 Apr:76:103379.
- Gary Han Chang , Meng-Yun Wu , Ling-Hui Yen , Da-Yu Huang , Ya-Hui Lin , Yu-Ru Luo , Ya-Ding Liu , Bin Xu , Kam W. Leong , Wen-Sung Lai , Ann-Shyn Chiang , Kuo-Chuan Wang , Chin-Hsien Lin , Shih-Luen Wang , Li-An Chu*. Isotropic Multi-Scale Neuronal Reconstruction from High-Ratio Expansion Microscopy with Contrastive Unsupervised Deep Generative Models. Computer Methods and Programs in Biomedicine. 2024 Feb;244:107991.
- Gary Han Chang , Meng-Yun Wu , Ling-Hui Yen , Da-Yu Huang , Ya-Hui Lin , Yu-Ru Luo , Ya-Ding Liu , Bin Xu , Kam W. Leong , Wen-Sung Lai , Ann-Shyn Chiang , Kuo-Chuan Wang , Chin-Hsien Lin , Shih-Luen Wang , Li-An Chu*. Isotropic Multi-Scale Neuronal Reconstruction from High-Ratio Expansion Microscopy with Contrastive Unsupervised Deep Generative Models. Computer Methods and Programs in Biomedicine. 2024 Feb;244:107991.
- Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin*, Shu-Chun Teng*.
The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. BMC Biol 2023 Dec 18;21(1):293.
- Szu-Ju Chen#, Yu-Jun Wu#, Chieh-Chang Chen, Yu-Wei Wu, Jyh-Ming Liou, Ming-Shiang Wu, Ching-Hua Kuo*, Chin-Hsien Lin*. Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease. npj Parkinson’s Disease 2023 Dec 14;9(1):165. doi: 10.1038/s41531-023-00612-y.
- Qing Wang, Hang Zhou, Bibiao Shen, Zifeng Huang, Shuzhen Zhu, Wanlin Yang, Fen Xie, Yuqi Luo, Feilan Yuan, Zhaohua Zhu, Chao Deng, Wenhua Zheng, Chengwu Yang, Chin-Hsien Lin, Bin Xiao, and EK Tan. Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease. npj Parkinson’s Disease 2023 Dec 13;9(1):163.
- Pin-Shiuan Chen, Ni-Chung Lee, Chieh-Ju Sung, Ya-Wen Liu, Wen-Chin Weng, MD, Pi-Chuan Fan, Wang-Tso Lee, Yin-Hsiu Chien, Chao-Szu Wu, Yueh-Feng Sung, Ming-Chen Tsai, Yi-Chung Lee, Hsueh-Wen Hsueh, Sabrina Mai-Yi Fan, Meng-Chen Wu, Hsun Li, Huan-Yun Chen, Han-I Lin, Chih-Hsin Ou-Yang, Wuh-Liang Hwuh, Chin-Hsien Lin.* Phenotypic heterogeneity in patients with mutations in the mitochondrial complex I assembly gene NDUFAF5. Movement Disorders 2023 Dec;38(12):2217-2229.
- John Yu, Hsiu-Hui Tsai, Hsiao-Jung Kao, Ming-Wei Kuo, Chin-Hsien Lin, Chin-Min Chang, Yi-Yin Chen, Hsiao-Huei Chen, Pui-Yan Kwok, and Alice Yu. Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing. Nature Communications 2023 Aug 25;14(1):5183. doi: 10.1038/s41467-023-40901-x.
- Yung-Tsai Chu, Chin-Feng Yu, Sung-Pin Fan, Ta-Fu Chen, Ming-Jang Chiu, Jyh-Shing Roger Jang, Shu-I Chiu*, Chin-Hsien Lin*.Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson’s disease. J Neurol Sci 2023 Aug 15;451:120731.
- Meng-Chen Wu, Yung-Yee Chang, Min-Yu Lan, Ying-Fa Chen, Chun-Hwei Tai, Szu-Ju Chen, Chin-Hsien Lin*. Blood neurofilament light chain as a surrogate marker for dystonia. European Journal of Neurology 2023 Oct;30(10):3098-3104.
- Yi-Cheng Tai, Peng-Hsiang Liao, Valentina Leta, Chin-Hsien Lin*, K Ray Chaudhuri. Irritable bowel syndrome based on Rome IV diagnostic criteria associates with non-motor symptoms of Parkinson’s disease. Parkinsonism & Related Disorders. 2023 Aug;113:105496.
- 書籍及篇章：
