Ming-Shiang Wu

吳明賢院長

吳明賢醫師現任台大醫院院長及台大醫學院內科特聘教授，目前也擔任台灣醫學會與台灣內科醫學會的理事長。主要研究領域包括腸胃學、分子生物學、幽門桿菌(Helicobacter pylori)及腸道菌群(gut microbiota)研究。吳院長在學術界表現卓越，發表了500多篇學術論文，並多次榮獲國內外學術獎項，包含科技部吳大猷紀念獎與科技部研究傑出獎，也榮獲工業技術研究院院士的殊榮。目前也擔任<>與<>等國際期刊編輯。

  • 著作：
  1. Chen, Y.-C., Malfertheiner, P., Yu, H.-T., Kuo, C.-L., Chang, Y.-Y., Meng, F.-T., Wu, Y.-X., Hsiao, J.-L., Chen, M.-J., Lin, K.-P., Wu, C.-Y., Lin, J.-T., Colm O’Morain, Megraud, F., Lee, W.-C., El-Omar, E. M., Wu, M.-S., & Liou, J.-M. (2024). Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology, 166(4). https://doi.org/10.1053/j.gastro.2023.12.022
  2. Hong, T.-C., El-Omar, E. M., Kuo, Y.-T., Wu, J.-Y., Chen, M.-J., Chen, C.-C., Fang, Y.-J., Hwong, A., Lu, H., Lin, J.-T., Tu, Y.-K., Yamaoka, Y., Wu, M.-S., Liou, J.-M., Hong, T.-C., El-Omar, E. M., Kuo, Y.-T., Wu, J.-Y., Chen, M.-J., & Chen, C.-C. (2024). Primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region between 1990 and 2022: an updated systematic review and meta-analysis. ˜the œLancet. Gastroenterology & Hepatology, 9(1), 56–67. https://doi.org/10.1016/s2468-1253(23)00281-9
  3. Lyu, Q., Chen, R.-A., Chuang, H.-L., Zou, H.-B., Liu, L., Sung, L.-K., Liu, P.-Y., Wu, H.-Y., Chang, H.-Y., Cheng, W.-J., Wu, W.-K., Wu, M.-S., & Hsu, C.-C. (2024). Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine. Gut Microbes, 16(1). https://doi.org/10.1080/19490976.2023.2300847
  4. Chen, P.-Y., Tsai, F.-P., Chen, M.-J., Yang, H.-Y., Wu, M.-S., & Liou, J.-M. (2023). Vonoprazan-based versus proton pump inhibitor-based therapy inHelicobacter pylorieradication: an updated systematic review and meta-analysis of randomised trials. Gut, gutjnl-329826. https://doi.org/10.1136/gutjnl-2023-329826
  5. Chen, M.-J., Bair, M.-J., Chen, P.-Y., Lee, J.-Y., Yang, T.-H., Fang, Y.-J., Chen, C.-C., Chang, A.-T., Hsiao, W.-D., Yu, J.-J., Kuo, C.-C., Chiu, M.-C., Lin, K.-P., Tsai, M.-H., Hsu, Y.-C., Chou, C.-K., Chen, C.-Y., Lin, J.-T., Lee, Y.-C., & Wu, M.-S. (2022). Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis. Helicobacter, 27(5). https://doi.org/10.1111/hel.12914
  6. Suraphan Panyod, Wu, W.-K., Hsieh, Y.-C., Tseng, Y.-J., Peng, S.-Y., Chen, R.-A., Huang, H.-S., Chen, Y.-H., Ting-Chin David Shen, Ho, C.-T., Liu, C.-J., Chuang, H.-L., Huang, C.-C., Wu, M.-S., & Sheen, L.-Y. (2024). Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice. Nutrition and Diabetes, 14(1). https://doi.org/10.1038/s41387-024-00306-1
  7. Lei, W., Lee, J.-Y., Chuang, S., Bair, M., Chen, C., Jeng Yih Wu, Wu, D., Felice Tien O’Donnell, Tien, H.-W., Chen, Y.-R., Chiang, T., Hsu, Y., Hsu, T., Hsieh, P.-C., Lin, L., Chia, S., Wu, C.-C., Yi‐Maun Subeq, Wen, S., & Chang, H.-C. (2023). EradicatingHelicobacter pylorivia13C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method. Gut, 72(12), 2231–2240. https://doi.org/10.1136/gutjnl-2023-329871
  8. Chen, S.-J., Wu, Y.-J., Chen, C.-C., Wu, Y.-W., Liou, J.-M., Wu, M.-S., Kuo, C.-H., & Lin, C.-H. (2023). Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease. Npj Parkinson S Disease, 9(1). https://doi.org/10.1038/s41531-023-00612-y
  9. Liu, W.-D., Wang, J.-T., Shih, M.-C., Chen, K.-H., Huang, S.-T., Huang, C.-F., Chang, T.-H., Tsai, M.-J., Kuo, P.-H., Yeh, Y.-C., Tsai, W.-C., Pan, M.-Y., Li, G.-C., Chen, Y.-J., Lin, K.-Y., Huang, Y.-S., Cheng, A., Chen, P.-Y., Pan, S.-C., & Sun, H.-Y. (2024). Effect of Early Dexamethasone on Outcomes of COVID-19: A Quasi-experimental Study Using Propensity Score Matching. Journal of Microbiology Immunology and Infection. https://doi.org/10.1016/j.jmii.2024.02.002
  10. Lee, Y.-C., Chiang, T.-H., Chiu, H.-M., Su, W.-W., Chou, K.-C., Chen, S. L.-S., Yen, A. M.-F., Fann, J. C.-Y., Chiu, S. Y.-H., Chuang, S.-L., Chen, Y.-R., Chen, S.-D., Hu, T.-H., Fang, Y.-J., Wu, M.-S., Chen, T. H.-H., Yeh, Y.-P., Lin , J.-T., Wu, C.-Y., & Liou, J.-M. (2024). Screening for Helicobacter pylori to Prevent Gastric Cancer. JAMA. https://doi.org/10.1001/jama.2024.14887
  11. Chen, Y., Wu, M., Wang, S.-H., Yin Ju Lien, Liao, S., Chang, C., Huang, W., Wu, C., & Hsu, C. (2024). Effectiveness of health checkup with depression screening on depression treatment and outcomes in middle-aged and older adults: a target trial emulation study. The Lancet Regional Health – Western Pacific, 43, 100978–100978. https://doi.org/10.1016/j.lanwpc.2023.100978
  12. Suraphan Panyod, Wu, W.-K., Hu, M.-Y., Huang, H.-S., Chen, R.-A., Chen, Y.-H., Ting-Chin David Shen, Ho, C.-T., Liu, C.-J., Chuang, H.-L., Huang, C.-C., Wu, M.-S., & Sheen, L.-Y. (2024). Healthy diet intervention reverses the progression of NASH through gut microbiota modulation. Microbiology Spectrum, 12(1). https://doi.org/10.1128/spectrum.01868-23
  13. Chen, C.-C., Tseng, P.-H., Hsueh, H.-W., Chiang, M.-C., Tzeng, S.-R., Tsung Hsien Chiang, Wu, M.-S., Hsieh, S.-T., & Chao, C.-C. (2024). Altered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-56984-5
  14. Suraphan Panyod, Wu, W.-K., Chang, C.-T., Wada, N., Ho, H.-C., Lo, Y.-L., Tsai, S.-P., Chen, R.-A., Huang, H.-S., Liu, P.-Y., Chen, Y.-H., Chuang, H.-L., Ting-Chin David Shen, Tang, S.-L., Ho, C.-T., Wu, M.-S., & Sheen, L.-Y. (2024). Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06224-3
  15. Hsu, W.-F., Chang, W.-Y., Kuo, C.-Y., Chang, L.-C., Lin, H.-H., Wu, M.-S., & Chiu, H.-M. (2024). The Effect of Novel AI-based Cecum Recognition System on Adenoma Detection Metrics at Screening Colonoscopy Setting. Gastrointestinal Endoscopy. https://doi.org/10.1016/j.gie.2024.09.019
  16. Liu, Y.-T., Wu, W.-H., Tseng, W.-T., Lin, H.-C., Wu, M.-S., Chen, P.-F., & Wu, I-Chien. (2023). Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus–A Nationwide Community-based study. Journal of Psychosomatic Research, 174, 111492. https://doi.org/10.1016/j.jpsychores.2023.111492
  17. Hu, K.-Y., Tseng, P.-H., Hsu, W.-C., Lee, P.-L., Tu, C.-H., Chen, C.-C., Lee, Y.-C., Chiu, H.-M., Wu, M.-S., & Peng, C.-K. (2024). Association of self-reported and objective sleep disturbance with the spectrum of gastroesophageal reflux disease. Journal of Clinical Sleep Medicine, 20(6), 911–920. https://doi.org/10.5664/jcsm.11028
  18. Lee, Y.-P., Chiu, C.-C., Chang, Y.-C., Chen, Y.-H., Wu, W.-K., Wu, M.-S., & Chuang, H.-L. (2024). Different bacteria species lipopolysaccharide co-exposure with NASH diet exacerbate NASH and liver fibrosis progress in mice. Clinics and Research in Hepatology and Gastroenterology, 102470. https://doi.org/10.1016/j.clinre.2024.102470
  19. Chou, C.-Y., Chiang, P.-C., Li, C.-C., Chang, J.-W., Lu, P.-H., Hsu, W.-F., Chang, L.-C., Hsu, J.-L., Wu, M.-S., & Wo, A. M. (2024). Improving the Purity of Extracellular Vesicles by Removal of Lipoproteins from Size Exclusion Chromatography- and Ultracentrifugation-Processed Samples Using Glycosaminoglycan-Functionalized Magnetic Beads. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.4c03869
  20. Liao, P.-H., Tung, H.-Y., Wee Shin Lim, Jyh-Shing Roger Jang, Li, H., Shun, C.-T., Chiu, H.-M., Wu, M.-S., & Lin, C.-H. (2024). Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson’s disease. Neurological Sciences. https://doi.org/10.1007/s10072-024-07641-2
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