Chin-Hsien Lin - CARES健康促進聯盟 | CARES Health Promotion Allianc

Chin-Hsien LinDoctor

Dr. Chin-Hsien Lin is a professor in the Department of Neurology at National Taiwan University Hospital, holding joint appointments in the Institutes of Molecular Medicine, Biomedical Engineering, and Mind, Brain, and Consciousness at the National Taiwan University College of Medicine. Clinically, she serves as the Director of the Clinical Neurology and Behavioral Medicine Center at NTUH. Dr. Lin’s research focuses on Parkinson’s disease, movement disorders, neurodegenerative diseases, the gut-brain axis, and neurogenetic medicine, with her work published in well-regarded national and international journals and widely cited. Due to her research achievements, Dr. Lin has been invited to serve on numerous international committees, including as a member of the Education Committee of the World Federation of Neurology, a member of the Scientific Committee of the International Parkinson and Movement Disorder Society, and as President of the Taiwan Movement Disorders Society.

Email：wjliao@ntu.edu.com

Publications
- 1. 1. Sung-Pin Fan, Ya-Fang Chen, Cheng-Hsuan Li, Yih-Chih Kuo, Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu, Tai-Chung Tseng, Tung-Hung Su, Chien-Ting Hsu, Huey-Ling Chen, Chin-Hsien Lin*, Yen-Hsuan Ni*. Topographical metal burden correlates with brain atrophy and clinical severity in Wilson’s disease. Neuroimage 2024, in press.
    1. Jagota P, Phutrakool P, Kamble N, Dang THT, Aldaajani Z, Hatano T, Hoskere Sreenivasa DK, Tripura T, Kukkle PL, Jeon B, Nishikawa N, Oji Y, Tran TN, Susatia F, Fabbri M, Leung C, Alonso Canovas A, Kamel WA, Pal PK, Rakesh K, Abu Snineh M, Chairangsaris P, Lolekha P, Jamora RDG, Mohamed Ibrahim N, Desa SHM, Tan AH, Toh TS, Obaid M, Fung VSC, Lang A, Lin CH, Regragui W, Bouslam N, Bhidayasiri R. Exercise Habits in People with Parkinson’s: A Multinational Survey. Mov Disord Clin Pract 2024 Aug 29. doi: 10.1002/mdc3.14197.
    2. Norlinah Mohamed Ibrahim* and Chin-Hsien Lin*. Early Onset Parkinsonism: Differential diagnosis and what not to miss. Parkinsonism & Related Disorders. 2024 Aug 15:107100. doi: 10.1016/j.parkreldis.2024.107100.
    3. Peng-Hsiang Liao, Hsiao-Yen Tung, Wee Shin Lim, Jyh-Shing Roger Jang, Hsun Li, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu, Chin-Hsien Lin*. Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson’s disease. Neurological Sciences. 2024 in press.
    4. Sung-Ju Hsueh, Chin-Hsien Lin, Ni-Chung Lee, Tung-Ming Chang, Sung-Pin Fan, Wan-De Huang, Yea-Huey Lin, Li-Kai Tsai, Yin-Hsiu Chien, Ming-Jen Lee, Wuh-Liang Hwu, Hsueh Wen Hsueh*, Chih-Chao Yang*. Unique clinical and electrophysiological features in the peripheral nerve system in patients with sialidosis – a case series study. Orphanet J Rare Dis 2024 May 24;19(1):217.
    5. Lin YH, Wang LW, Chen YH, Chan YC, Hu SH, Wu SY, Chiang CS, Huang GJ, Yang SD, Chu SW, Wang KC, Lin CH, Huang PH, Cheng HJ, Chen BC, Chu LA. Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain. Elife. 2024 May 22;13:RP93212. doi: 10.7554/eLife.93212.
    6. Chang JC, Chang HS, Chao YC, Huang CS, Lin CH, Wu ZS, Chang HJ, Liu CS, Chuang CS. Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport. Biology (Basel). 2024;13(4):231.
    7. Huan-Yun Chen, Chia-Yu Liao, Hsun Li. Yi-Ci Ke Lin, Chin-Hsien Lin,* Teng, Shu-Chun*. ATM-mediated co-chaperone DNAJB11 phosphorylation facilitates α-synuclein folding upon DNA double-stranded breaks. NAR Molecular Medicine. 2024 in press
    8. Pin-Shiuan Chena, Ying-Fa Chen, Jian-Ying Chiu, Meng-Chen Wu, MD, Chun-Hwei Tai, Yung-Yee Chang, Min-Yu Lan, Han-I Lin, Ni-Chung Lee, Chin-Hsien Lin*. Genetic analysis of IRF2BPL in a Taiwanese dystonia cohort:
    the genotype and phenotype correlation. Annals of Clinical and Translational Neurology 2024, in press.
    1. Tiago F Outeiro, Lorraine V Kalia, Erwan Bezard, Juan Ferrario, Chin-Hsien Lin, Mohamed Salama, David G Standaert, Lolade Taiwo, Ryosuke Takahashi, Miquel Vila, Brit Mollenhauer, Per Svenningsson*; MDS Basic Science Special Interest Group Steering Committee. Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice. Mov Disord 2024 Apr 4. doi: 10.1002/mds.29802.
    1. Chih-Hsin Ou-Yang, Pin-Shiuan Chen, Chin-Hsien Lin*. Generation of a human induced pluripotent stem cell line NTUHi004-A from a patient with Leigh syndrome harboring a homozygous missense mutation c.836 T > G (p.Met279Arg) in NDUFAF5 gene. Stem Cell Research 2024 Apr:76:103379.
    2. Gary Han Chang , Meng-Yun Wu , Ling-Hui Yen , Da-Yu Huang , Ya-Hui Lin , Yu-Ru Luo , Ya-Ding Liu , Bin Xu , Kam W. Leong , Wen-Sung Lai , Ann-Shyn Chiang , Kuo-Chuan Wang , Chin-Hsien Lin , Shih-Luen Wang , Li-An Chu*. Isotropic Multi-Scale Neuronal Reconstruction from High-Ratio Expansion Microscopy with Contrastive Unsupervised Deep Generative Models. Computer Methods and Programs in Biomedicine. 2024 Feb;244:107991.
    3. Ya-Lan Chang, Chan-Chih Yang, Yun-Yu Huang, Yi-An Chen, Chia-Wei Yang, Chia-Yu Liao, Hsun Li, Ching-Shyi Wu, Chin-Hsien Lin*, Shu-Chun Teng*.
    The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. BMC Biol 2023 Dec 18;21(1):293.
    1. Szu-Ju Chen#, Yu-Jun Wu#, Chieh-Chang Chen, Yu-Wei Wu, Jyh-Ming Liou, Ming-Shiang Wu, Ching-Hua Kuo*, Chin-Hsien Lin*. Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease. npj Parkinson’s Disease 2023 Dec 14;9(1):165. doi: 10.1038/s41531-023-00612-y.
    2. Qing Wang, Hang Zhou, Bibiao Shen, Zifeng Huang, Shuzhen Zhu, Wanlin Yang, Fen Xie, Yuqi Luo, Feilan Yuan, Zhaohua Zhu, Chao Deng, Wenhua Zheng, Chengwu Yang, Chin-Hsien Lin, Bin Xiao, and EK Tan. Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease. npj Parkinson’s Disease 2023 Dec 13;9(1):163.
    3. Vollstedt EJ, Madoev H, Aasly A, Ahmad-Annuar A, Al-Mubarak B, Alcalay RN, Alvarez V, Amorin I, Annesi G, Arkadir D, Bardien S, Barker RA, Barkhuizen M, Basak AN, Bonifati V, Boon A, Brighina L, Brockmann K, Carmine Belin A, Carr J, Clarimon J, Cornejo-Olivas M, Correia Guedes L, Corvol JC, Crosiers D, Damásio J, Das P, de Carvalho Aguiar P, De Rosa A, Dorszewska J, Ertan S, Ferese R, Ferreira J, Gatto E, Genç G, Giladi N, Gómez-Garre P, Hanagasi H, Hattori N, Hentati F, Hoffman-Zacharska D, Illarioshkin SN, Jankovic J, Jesús S, Kaasinen V, Kievit A, Klivenyi P, Kostic V, Koziorowski D, Kühn AA, Lang AE, Lim SY, Lin CH, Lohmann K, Markovic V, Martikainen MH, Mellick G, Merello M, Milanowski L, Mir P, Öztop-Çakmak Ö, Pimentel MMG, Pulkes T, Puschmann A, Rogaeva E, Sammler EM, Skaalum Petersen M, Skorvanek M, Spitz M, Suchowersky O, Tan AH, Termsarasab P, Thaler A, Tumas V, Valente EM, van de Warrenburg B, Williams-Gray CH, Wu RM, Zhang B, Zimprich A, Solle J, Padmanabhan S, Klein C. Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project. PLoS One. 2023 Oct 3;18(10):e0292180.
    4. Pin-Shiuan Chen, Ni-Chung Lee, Chieh-Ju Sung, Ya-Wen Liu, Wen-Chin Weng, MD, Pi-Chuan Fan, Wang-Tso Lee, Yin-Hsiu Chien, Chao-Szu Wu, Yueh-Feng Sung, Ming-Chen Tsai, Yi-Chung Lee, Hsueh-Wen Hsueh, Sabrina Mai-Yi Fan, Meng-Chen Wu, Hsun Li, Huan-Yun Chen, Han-I Lin, Chih-Hsin Ou-Yang, Wuh-Liang Hwuh, Chin-Hsien Lin.* Phenotypic heterogeneity in patients with mutations in the mitochondrial complex I assembly gene NDUFAF5. Movement Disorders 2023 Dec;38(12):2217-2229.
    5. John Yu, Hsiu-Hui Tsai, Hsiao-Jung Kao, Ming-Wei Kuo, Chin-Hsien Lin, Chin-Min Chang, Yi-Yin Chen, Hsiao-Huei Chen, Pui-Yan Kwok, and Alice Yu. Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing. Nature Communications 2023 Aug 25;14(1):5183. doi: 10.1038/s41467-023-40901-x.
    19. Yung-Tsai Chu, Chin-Feng Yu, Sung-Pin Fan, Ta-Fu Chen, Ming-Jang Chiu, Jyh-Shing Roger Jang, Shu-I Chiu*, Chin-Hsien Lin*.Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson’s disease. J Neurol Sci 2023 Aug 15;451:120731.